The expression of PODXL was associated with the migratory ability of human oral squamous cell carcinoma (OSCC). In the present study, we found that podocalyxin-like 1 (PODXL), a cell surface glycoprotein, was overexpressed in cancer tissues and was upregulated in lymph node metastatic tumor cells. Identifying tumor-specific biomarkers is critical for the development of diagnostic and therapeutic tools. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.Metastasis-mediated death remains a major challenge in cancer treatment due to the lack of identifiable biomarkers for early diagnosis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Induces the formation of apical actin-dependent microvilli. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Involved in the regulation of both adhesion and cell morphology and cancer progression. Gp200, PC, PCLP, PCLP-1, PCB, AW121214, Ly102, Pclp1, podocalyxin, MEP21, PODXL, Gp135, PCLP1, cPCLP1, podxl, fc18d02, wu:fc18d02, Pc, Pcb, Podxl, podocalyxin like, pyruvate carboxylase, podocalyxin-like, PODXL, PC, Podxl, podxl, Pcx Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Rat (Rattus)). Xing, Ye, Chen, Hu, Chen: "Hydrochloride pioglitazone protects diabetic rats against podocyte injury through preserving glomerular podocalyxin expression." in: Arquivos brasileiros de endocrinologia e metabologia, Vol. References for anti-PODXL antibody (ABIN675264) (hide).This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. Annexin V-FITC Apoptosis Detection KitsĪqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
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